A disadvantage of using OPV is its risk of VAPP. Which additional risk does OPV pose?

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Study for the Poliovirus and Poliomyelitis Test. Prepare with engaging flashcards and detailed multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Multiple Choice

A disadvantage of using OPV is its risk of VAPP. Which additional risk does OPV pose?

Explanation:
Oral polio vaccine is a live attenuated vaccine given by mouth, which not only protects the vaccinated person but can also spread to others, helping to stop transmission. This live virus can shed in stool and circulate in communities. In areas with low vaccination coverage, that circulating vaccine virus can mutate and revert to a form that can cause disease, creating circulating vaccine-derived polioviruses. This is the additional risk OPV poses beyond the small chance of vaccine-associated paralytic poliomyelitis. In contrast, the inactivated polio vaccine uses killed virus and does not carry this circulation risk.

Oral polio vaccine is a live attenuated vaccine given by mouth, which not only protects the vaccinated person but can also spread to others, helping to stop transmission. This live virus can shed in stool and circulate in communities. In areas with low vaccination coverage, that circulating vaccine virus can mutate and revert to a form that can cause disease, creating circulating vaccine-derived polioviruses. This is the additional risk OPV poses beyond the small chance of vaccine-associated paralytic poliomyelitis. In contrast, the inactivated polio vaccine uses killed virus and does not carry this circulation risk.

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