In the poliovirus genome, where is the IRES located?

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Study for the Poliovirus and Poliomyelitis Test. Prepare with engaging flashcards and detailed multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Multiple Choice

In the poliovirus genome, where is the IRES located?

Explanation:
The key idea is that poliovirus initiates protein synthesis using an internal ribosome entry site that sits in the 5' noncoding region of its genome. This 5' UTR contains the IRES, which brings the ribosome to the RNA and starts translation of the single long polyprotein without needing a 5' cap. Since the IRES is in the 5' noncoding region, not in the coding sequence or within a structural gene like VP1, and not in the 3' end, it specifically resides in the 5' UTR. This arrangement enables the virus to hijack the host translation machinery in a cap-independent manner.

The key idea is that poliovirus initiates protein synthesis using an internal ribosome entry site that sits in the 5' noncoding region of its genome. This 5' UTR contains the IRES, which brings the ribosome to the RNA and starts translation of the single long polyprotein without needing a 5' cap. Since the IRES is in the 5' noncoding region, not in the coding sequence or within a structural gene like VP1, and not in the 3' end, it specifically resides in the 5' UTR. This arrangement enables the virus to hijack the host translation machinery in a cap-independent manner.

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