In the post-switch era, which serotype-derived outbreaks continue to be a major concern?

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Study for the Poliovirus and Poliomyelitis Test. Prepare with engaging flashcards and detailed multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Multiple Choice

In the post-switch era, which serotype-derived outbreaks continue to be a major concern?

Explanation:
After the switch from trivalent to bivalent OPV, removing the type 2 component, immunity to type 2 can wane in populations with insufficient vaccination coverage. The attenuated type 2 virus from OPV can continue to circulate, accumulating mutations that restore neurovirulence and spread in under-immunized communities. Without the routine use of a type 2-containing vaccine in OPV, these vaccine-derived type 2 viruses keep reappearing as outbreaks, making cVDPV2 the major ongoing concern in the post-switch era. Outbreaks of cVDPV1 or cVDPV3 do occur, but they have not shown the same global persistence and scale as cVDPV2.

After the switch from trivalent to bivalent OPV, removing the type 2 component, immunity to type 2 can wane in populations with insufficient vaccination coverage. The attenuated type 2 virus from OPV can continue to circulate, accumulating mutations that restore neurovirulence and spread in under-immunized communities. Without the routine use of a type 2-containing vaccine in OPV, these vaccine-derived type 2 viruses keep reappearing as outbreaks, making cVDPV2 the major ongoing concern in the post-switch era. Outbreaks of cVDPV1 or cVDPV3 do occur, but they have not shown the same global persistence and scale as cVDPV2.

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