Vaccine-derived polioviruses originate from mutations in which vaccine?

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Study for the Poliovirus and Poliomyelitis Test. Prepare with engaging flashcards and detailed multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Multiple Choice

Vaccine-derived polioviruses originate from mutations in which vaccine?

Explanation:
Vaccine-derived polioviruses come from the live, attenuated virus used in the oral poliovirus vaccine. Because this vaccine contains a weakened but replicating virus, it can multiply in the gut and occasionally acquire mutations that restore virulence. In communities with low vaccination coverage, this mutated virus can spread from person to person and evolve into a circulating vaccine-derived poliovirus capable of causing paralysis. Other vaccines listed use inactivated or non-replicating components, so they cannot replicate or mutate into virulent forms and cannot produce vaccine-derived polioviruses.

Vaccine-derived polioviruses come from the live, attenuated virus used in the oral poliovirus vaccine. Because this vaccine contains a weakened but replicating virus, it can multiply in the gut and occasionally acquire mutations that restore virulence. In communities with low vaccination coverage, this mutated virus can spread from person to person and evolve into a circulating vaccine-derived poliovirus capable of causing paralysis. Other vaccines listed use inactivated or non-replicating components, so they cannot replicate or mutate into virulent forms and cannot produce vaccine-derived polioviruses.

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