What is the estimated occurrence of VAPP with OPV?

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Study for the Poliovirus and Poliomyelitis Test. Prepare with engaging flashcards and detailed multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Multiple Choice

What is the estimated occurrence of VAPP with OPV?

Explanation:
VAPP, or vaccine-associated paralytic poliomyelitis, happens when the attenuated poliovirus in the oral polio vaccine reverts to a neurovirulent form and causes paralysis in the vaccine recipient or someone exposed to it. Based on population surveillance data, the estimated rate is about one VAPP case for every 2.5 million doses of OPV. That makes the 1 in 2.5 million doses estimate the best match. Other rates are not consistent with the long-run surveillance figures. Note that this risk is specific to OPV; inactivated polio vaccine does not carry VAPP risk because it uses killed virus.

VAPP, or vaccine-associated paralytic poliomyelitis, happens when the attenuated poliovirus in the oral polio vaccine reverts to a neurovirulent form and causes paralysis in the vaccine recipient or someone exposed to it. Based on population surveillance data, the estimated rate is about one VAPP case for every 2.5 million doses of OPV. That makes the 1 in 2.5 million doses estimate the best match. Other rates are not consistent with the long-run surveillance figures. Note that this risk is specific to OPV; inactivated polio vaccine does not carry VAPP risk because it uses killed virus.

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