What is vaccine-associated paralytic poliomyelitis (VAPP)?

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Study for the Poliovirus and Poliomyelitis Test. Prepare with engaging flashcards and detailed multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Multiple Choice

What is vaccine-associated paralytic poliomyelitis (VAPP)?

Explanation:
Vaccine-associated paralytic poliomyelitis occurs when the oral polio vaccine, which contains a live attenuated virus, occasionally reverts to a neurovirulent form. That reversion allows the vaccine-derived virus to replicate and reach the nervous system, causing paralysis in the vaccinated person or in a close contact who is exposed to shed virus. It is a rare event, not a common side effect, and it reflects a consequence of using a live-virus vaccine. This paralysis can look like wild poliomyelitis, but its origin is the vaccine strain rather than wild poliovirus. Using the inactivated polio vaccine, which contains no live virus, avoids this risk.

Vaccine-associated paralytic poliomyelitis occurs when the oral polio vaccine, which contains a live attenuated virus, occasionally reverts to a neurovirulent form. That reversion allows the vaccine-derived virus to replicate and reach the nervous system, causing paralysis in the vaccinated person or in a close contact who is exposed to shed virus. It is a rare event, not a common side effect, and it reflects a consequence of using a live-virus vaccine. This paralysis can look like wild poliomyelitis, but its origin is the vaccine strain rather than wild poliovirus. Using the inactivated polio vaccine, which contains no live virus, avoids this risk.

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