Which cells are primarily affected in poliovirus CNS infection?

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Study for the Poliovirus and Poliomyelitis Test. Prepare with engaging flashcards and detailed multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Multiple Choice

Which cells are primarily affected in poliovirus CNS infection?

Explanation:
Poliovirus in the CNS preferentially attacks motor neurons. It invades the anterior horn motor neurons of the spinal cord (and motor nuclei of the brainstem) and destroys them, producing the hallmark flaccid paralysis of poliomyelitis with muscle weakness and loss of reflexes while sensation is typically preserved. Islet cells, sensory neurons, and astrocytes are not the primary targets in this infection, which is why motor neurons are the best answer.

Poliovirus in the CNS preferentially attacks motor neurons. It invades the anterior horn motor neurons of the spinal cord (and motor nuclei of the brainstem) and destroys them, producing the hallmark flaccid paralysis of poliomyelitis with muscle weakness and loss of reflexes while sensation is typically preserved. Islet cells, sensory neurons, and astrocytes are not the primary targets in this infection, which is why motor neurons are the best answer.

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