Why was there a global shift away from OPV?

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Study for the Poliovirus and Poliomyelitis Test. Prepare with engaging flashcards and detailed multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Multiple Choice

Why was there a global shift away from OPV?

Explanation:
The main reason for shifting away from OPV is to eliminate vaccine-derived risks. OPV uses a live, weakened virus that can, in rare cases, mutate and cause vaccine-associated paralytic polio or circulating vaccine-derived polioviruses in under-immunized populations. As wild poliovirus transmission declined, the safety concern from live-virus strains became the limiting factor, so many programs switched to the inactivated vaccine, which cannot cause these vaccine-derived problems. Cost and logistics are considerations, but the primary driver is protecting against vaccine-derived disease.

The main reason for shifting away from OPV is to eliminate vaccine-derived risks. OPV uses a live, weakened virus that can, in rare cases, mutate and cause vaccine-associated paralytic polio or circulating vaccine-derived polioviruses in under-immunized populations. As wild poliovirus transmission declined, the safety concern from live-virus strains became the limiting factor, so many programs switched to the inactivated vaccine, which cannot cause these vaccine-derived problems. Cost and logistics are considerations, but the primary driver is protecting against vaccine-derived disease.

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